Application | Comment | Organism |
---|---|---|
analysis | the enzyme is a marker for the murine X-zone | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of 20alpha-HSD knockout animals, 20alpha-HSD is not required for the regulation of X-zone growth | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Mus musculus | |
0.0033 | - |
11-deoxycorticosterone | pH 7.4, 37°C | Mus musculus | |
0.0058 | - |
17alpha-hydroxyprogesterone | pH 7.4, 37°C | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activates | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + NAD(P)H | Mus musculus | progesterone catabolism | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
17alpha-hydroxyprogesterone + NAD(P)H | Mus musculus BALB/c | progesterone catabolism | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
additional information | Mus musculus | pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview | ? | - |
? | |
additional information | Mus musculus BALB/c | pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Balb/c mice | - |
Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Mus musculus | - |
adrenal gland | high expression level, expression is restricted to the X-zone, adrenal 20alpha-HSD activity in male mice peaks at 3 weeks of age and disappears thereafter, whereas 20alpha-HSD enzyme activity is maintained in adrenals from nulliparous female animals | Mus musculus | - |
kidney | - |
Mus musculus | - |
ovary | high expression level | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
progesterone concentration in blood and tissues, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + NAD(P)H | - |
Mus musculus | 4-pregnen-20alpha,21-diol-3-one + NAD(P)+ | - |
? | |
11-deoxycorticosterone + NAD(P)H | - |
Mus musculus BALB/c | 4-pregnen-20alpha,21-diol-3-one + NAD(P)+ | - |
? | |
17alpha-hydroxyprogesterone + NAD(P)H | - |
Mus musculus | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
17alpha-hydroxyprogesterone + NAD(P)H | progesterone catabolism | Mus musculus | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
17alpha-hydroxyprogesterone + NAD(P)H | - |
Mus musculus BALB/c | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
17alpha-hydroxyprogesterone + NAD(P)H | progesterone catabolism | Mus musculus BALB/c | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
additional information | pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview | Mus musculus | ? | - |
? | |
additional information | pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview | Mus musculus BALB/c | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20alpha-HSD | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Mus musculus | |
NAD(P)H | - |
Mus musculus |